• Celecoxib Main Text These are exciting times for stem cell r

  2018-11-08

  

  Main Text These are exciting times for stem cell research and its application to human health. Unprecedented opportunities now exist to harness the power of stem Celecoxib to understand and treat disease. We continue to learn more about the potential of stem cells of many different types to contri

• A link between PARK and mitochondrial biology was

  2018-11-08

  

  A link between PARK2 and mitochondrial biology was first established in Drosophila, which displayed impairment in mitochondrial function and neuronal loss in an age-dependent manner when rendered deficient for PARK2 (Greene et al., 2003). Likewise, similar mitochondrial defects exhibited in Park2 kn

• br Materials and methods br Acknowledgements

  2018-11-08

  

  Materials and methods Acknowledgements This work was supported by grants from Instituto de Salud Carlos III (PI 15/000227 to MC, Plataforma en Red de Recursos Biomoleculares y BioinformaticosPRB2 PT13/0001/0042) cofunded by FEDER. Resource table. Resource details Loss-of-function mutation

• The seemingly shared ability of

  2018-11-08

  

  The seemingly shared ability of independently evolved (Extavour and Akam, 2003; Ewen-Campen et al., 2010) maternal germ plasm regulators to engage multiple proteins and RNA partners provide new insight and testable models for mechanisms by which germ plasm assembly, mitochondrial recruitment and Bal

• Mechanisms underlying CIPN include direct and indirect effec

  2018-11-08

  

  Mechanisms underlying CIPN include direct and indirect effects on sensory nerves such as damage to neuronal cell bodies in the dorsal root ganglion, alteration of the amplitude of the Calcium Ionophore I or conduction velocity (Argyriou et al., 2012; Sisignano et al., 2014). Whereas CIPN may be rev

• In proof of principle experiments

  2018-11-08

  

  In proof-of-principle experiments, we examined the response of hESC-derived CMs to verapamil and isoproterenol, two drugs commonly used in cardiovascular research. Single CMs exhibited a significantly reduced calcium transient amplitude associated with a negative inotropic response to treatment with

• ketotifen fumarate br Job shift and worker s

  2018-11-07

  

  Job shift and worker’s effort: theory and evidence from the literature Methodology and data Descriptive analysis In this section, I present a summary descriptive analysis related to the sample. The summary statistics for the sample are shown in Table 1. Initially, it is important to highlig

• br Introduction Scales that measure symptoms of narcolepsy e

  2018-11-07

  

  Introduction Scales that measure symptoms of narcolepsy emphasize rating clinical features of the disease such as excessive daytime sleepiness and cataplexy [1,2], but they may fail to capture the full functional impact of narcolepsy or its treatments. The Medical Outcomes Study Short Form-36 (SF

• br March y Levinthal describen que una empresa busca

  2018-11-07

  

  March (1991) y Levinthal (1998) describen que una empresa busca en principio la novedad para hacerse de uno o varios nichos y luego explotar los que resulten más beneficiosos. El proceso iniciaría de exploración de diseños (en productos, rutinas y organizaciones) al cual le continúa uno de explota

• In this issue of EBioMedicine Enroth and colleagues present

  2018-11-07

  

  In this issue of EBioMedicine, Enroth and colleagues () present a comprehensive study that analyzes the individual contribution of factors related to the collection and long-term sample storage in a highly homogenous group of Northern European subjects (). Taking advantage of the sampling strategy o

• order substance p In agreement with other studies Stein et a

  2018-11-07

  

  In agreement with other studies (Stein et al., 2009; Zhang et al., 2015; Lee et al., 2015) serum levels of the FGF-21 depend on renal functions because renal elimination is a major route by which physiological FGF-21 serum levels are maintained. Like other researches (Stein et al., 2009; Lee et al.,

• Munc proteins are known to facilitate formation of trans

  2018-11-07

  

  Munc18 proteins are known to facilitate formation of trans-SNARE complexes that mediate SG fusion (Sudhof and Rothman, 2009). β-cells express all three Munc18 isoforms, Munc18a, b, and c (Oh et al., 2012; Lam et al., 2013; Zhu et al., 2015). We recently reported Munc18c/Syn-4 complex\'s role in insu

• We first confirmed PDLIM overexpression in primary meningiom

  2018-11-07

  

  We first confirmed PDLIM2 overexpression in primary meningioma and schwannoma samples and showed that it is not expressed in HMC or normal meningeal tissue and minimally expressed in the Schwann cell examined. PDLIM2 was significantly knocked down in three primary meningioma and three primary schwan

• Alpha and beta tubulin are palmitoylated Caron and Herwood C

  2018-11-07

  

  Alpha and beta-tubulin are palmitoylated (Caron and Herwood, 2007; Caron et al., 2001; Zambito and Wolff, 1997; Ozols and Caron, 1997; Caron, 1997), and tubulin palmitoylation helps to anchor microtubule filaments in the plasma membrane and supports functions needed for cellular transport and divisi

• The findings of Liang and co workers add to current

  2018-11-07

  

  The findings of Liang and co-workers add to current knowledge on gastric and colorectal carcinogenesis, uncovering the cooperation between deranged genetic and epigenetic mechanism in two extensively studied tumor models. In addition, novel CRC prognostic biomarkers might allow for improved patient

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