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br Immunotherapy in melanoma had
2018-11-14
Immunotherapy in melanoma had a long history and tradition. Early efforts have been made with interferon-alpha and interleukin-2 in melanoma patients with the main focus to augment the function of immune cells to fight this deadliest type of skin cancer. Although a huge amount of experimental data
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br Results br Discussion For any new
2018-11-14
Results Discussion For any new technology a primary concern is safety and reactogenicity, especially for a vaccine that potentially contains powerful stimulators of the innate immune system. In these studies, we saw a correlation between dose and local reactions, but even at the highest dose o
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Loss of the first phase insulin response is believed to
2018-11-14
Loss of the first phase insulin response is believed to be the first detectable defect in beta-cell function (), thus men with optimal glucose regulation were at increased risk of cancer relative to those with less rapid glucose clearance. This is in contrast to most of the literature linking diabet
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Uno de los problemas m s importantes que se ven
2018-11-14
Uno de los problemas más importantes que se venían arrastrando desde el establecimiento del federalismo mexicano en 1824 fue la determinación de las facultades fiscales federales y locales. En 1917 se estableció que, de acuerdo con el artículo 124, “las facultades que no estén expresamente concedida
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br Experimental design materials and methods br Acknowledgme
2018-11-14
Experimental design, materials and methods Acknowledgments This work was supported by a Grant from the Swedish Cancer Society. Specifications Table Value of the data Data, experimental design, materials and methods Using a quantitative shotgun proteomic approach (nLC–ESI–MS/MS) we ha
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Affective memory biases a key element of the cognitive
2018-11-13
Affective memory biases, a key element of the cognitive (Disner et al., 2011) and neuropsychological models of MDD (Roiser and Sahakian, 2013), are a common finding (Dalgleish and Werner-Seidler, 2014; Bradley and Mathews, 1988). Dalgleish and Werner-Seidler (2014) highlight the key components of t
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From birth infants preferentially orient to voices and their
2018-11-13
From birth infants preferentially orient to voices and their prenatal hearing experiences in utero shape listening preferences exhibited as newborns (DeCasper and Fifer, 1980; DeCasper and Sigafoos, 1983; DeCasper and Spence, 1986; Ecklund-Flores and Turkewitz, 1996). Another line of research shows
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Introduction Physical activity and sleep are both recognized
2018-11-13
Introduction Physical activity and sleep are both recognized as important health determinants and represent critical targets for chronic disease prevention. A better understanding of the roles that these factors play in health and disease has been facilitated by the development and implementation o
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This issue of contains an article by
2018-11-13
This issue of contains an article by Yeh and Schenck about behavioral dyscontrol during sleep emerging with sporadic (non-familial) nocturnal frontal lobe epilepsy (NFLE) . A series of eight cases was reported, with video-polysomnography (vPSG) and sleep EEG documentation, and successful treatment
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UARS diagnosis is suspected in
2018-11-13
UARS diagnosis is suspected in individuals with complaints of excessive daytime sleepiness or daytime tiredness, no OSAS and a polysomnographic study with respiratory parameters indicative of increased upper airway resistance, such as, flow limitation during sleep. They present arousals associated w
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pak1 With paper thicknesses commonly ranging from to m
2018-11-13
With paper thicknesses commonly ranging from 50 to 400μm, light transmission measurements offer enhanced accuracy and sensitivity by interrogating the cumulative density of light absorbing particles throughout the thickness of the paper [7]. Further, sensitivity may be tuned by layering sheets of pa
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br Acknowledgements The research work has
2018-11-13
Acknowledgements The research work has been fully supported by the Higher Education Commission, Pakistan with Support initiative Grant No. IRSIP 21 Ps 04. I would like to thank the Department of Applied sciences of UWE, Bristol,UK for providing access to their lab facilities. Introduction Th
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Introducci n En los pa ses
2018-11-13
Introducción En los países industrializados hay salarios estancados, desempleo y reparto crecientemente desigual del ingreso y la riqueza, con retroceso de los estados benefactores. En muchas naciones en desarrollo, junto al congelamiento o lento avance de las remuneraciones salariales reales, se d
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Qui rase o no el
2018-11-13
Quiérase o no, el encogimiento relativo de las remuneraciones al trabajo es demasiado general para ser explicado por el abaratamiento en los precios de los bienes de capital y de las innovaciones incorporadas phosphodiesterase inhibitors los mismos, como inductores de la robotización y del reemplazo
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The median poverty rate was from to horizontal
2018-11-13
The median poverty rate was 13.4% from 1959 to 2012 (horizontal dashed line in Figure 1). It is clear that after the 1980\'s, the US XMD8-92 has been well above that point (see Figure 1). It can be noted that the best way to describe the growth rates of poverty in the United States is a line with a
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