• Based on the cumulative evidence of our previously

  2020-07-27

  

  Based on the cumulative evidence of our previously published work, we hypothesize that the 1,3-benzoxazine nucleus, with its altered electronic structure compared to the other scaffolds will retain the general binding capabilities for PI3K family members but will show modified selectivity profiles c

• br Hypothesis on DDR protective mode

  2020-07-27

  

  Hypothesis on DDR1 protective mode of action The documented protective role of DDR1 is quite impressive, demonstrated using different preclinical models (immunologic [46,54,58], obstructive [45], and hypertensive [50]) with different intervention paradigms: genetic ablation [45,50,58,72], silenci

• In conclusion it has been demonstrated that the hypermethyla

  2020-07-27

  

  In conclusion, it has been demonstrated that the hypermethylation of DAPK, RARbeta, MGMT, RASSF1A and FHIT is common not only in laryngeal cancer herpes simplex virus but also in paired normal epithelial cells from epiglottis or trachea. Moreover, the methylation of MGMT correlates with lymph node

• According to several authors MM

  2020-07-27

  

  According to several authors, MM is consistently preceded by a monoclonal gammopathy of uncertain significance (MGUS)—an asymptomatic (no CRAB criteria) premalignant entity that has been reported to have a transformation rate to MM of approximately 1% per year. Smoldering multiple myeloma (SMM) is a

• The methods of choice to assess collagen

  2020-07-27

  

  The methods of choice to assess collagen glycosylation range from the analysis of single amino acids following alkaline hydrolysis [13] up to liquid chromatography–tandem mass spectrometry (LC–MS/MS) [12,14,15]. The low complexity of the polypeptide sequence and the intermolecular/intramolecular co

• ApicomplexansApicomplexans are unicellular and spore forming

  2020-07-25

  

  ApicomplexansApicomplexans are unicellular and spore-forming obligate intracellular parasites that occupy diverse host niches (Mogi and Kita 2010). They have remodeled mitochondrial carbon and energy metabolism through reductive evolution. The development of novel drugs is now a very serious challen

• In vitro work by us

  2020-07-25

  

  In vitro work by us and others revealed that high affinity interaction with collagen requires dimerization and/or pre-oligomerization of DDR1 (Agarwal et al., 2007, Abdulhussein et al., 2008, Leitinger, 2003). It has also been reported that a significant percentage of the DDR1 population forms ligan

• Here we found that these leukotriene antagonists

  2020-07-25

  

  Here we found that these leukotriene antagonists also inhibit the effects of nucleotides acting at P2Y receptors in dU937 cells, which are known to express a number of nucleotide receptors, such as P2Y2 or P2Y4[30]. In an effort to characterize the P2 receptor subtypes subject to negative modulation

• The CPA EoS was presented

  2020-07-25

  

  The CPA EoS was presented by Kontogeorgis et al., in 1996 [23]. The proposed equation is composed of two parts (SRK EOS + association term) such that it can well predict the thermodynamic behavior of hydrogen bonding materials as a result of considering the association term. Yakoumis et al. (1997) e

• This study demonstrates that GUL

  2020-07-25

  

  This study demonstrates that GUL-1 affects multiple pathways/processes. As GUL-1 is likely to function as an RNA-binding protein, it is conceivable that the mRNAs involved are bound to GUL-1 as part of the regulatory function of the protein. In fact, in S. cerevisiae Ssd1 was shown to bind multiple

• Hence what is proposed here is a technique

  2020-07-25

  

  Hence, what is proposed here is a technique highly used in reliability engineering: Software Rejuvenation[4], [21], a technique of proactive fault tolerance in which the system is periodically reboot to clean the memory. In fact, it is well known that most critical SW failures are transient. These m

• Determination of relative potency EC by dose response assays

  2020-07-25

  

  Determination of relative potency (EC50) by dose response assays in vitro is subject to the same sources of variability as determination of affinity, since the EC50 and Hill slope of the dose response curve are highly dependent on the binding of ligand to a competing receptor that may be present, an

• In principle in vitro techniques for assessing

  2020-07-25

  

  In principle, in vitro techniques for assessing enzyme induction might include the use of cultured hepatocytes, precision-cut liver slices, immortalized Atglistatin lines (such as those derived from hepatomas) and reporter gene constructs (where appropriate cells are transfected with recombinant DNA

• Taken together these assays demonstrate that SUMOD

  2020-07-25

  

  Taken together, these assays demonstrate that SUMOD positioning is essential for all E3 ligases but dispensable for E2 and S*E2 sumoylation reactions. Thus, we propose SUMOD positioning as a key criterion to describe the enzymatic function of SUMO E3 ligases that distinguishes them from other enhanc

• The results showed that ethanol and acetaldehyde

  2020-07-24

  

  The results showed that ethanol and acetaldehyde production was not affected by the presence of CPA-7. We observed that the concentration of ethanol increased throughout the assay up to 95–179 μL L-1 regardless of the treatment. The acetaldehyde concentration reached its highest values after 6–9 day

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