• br STAR Methods br Acknowledgments This work was

  2021-09-24

  

  STAR★Methods Acknowledgments This work was supported by the American Diabetes Association (grant 1-12-BS-161 to J.D.P.), an NIH predoctoral T32 in Autoimmunity and Immunopathology grant (AI089443-05 to D.M.P.), the NIH (grant DK099550 to H.M.T.), the American Association for Cancer Research (S

• That MSCs release IL upon LPS stimulation or

  2021-09-24

  

  That MSCs release IL-6 upon LPS stimulation or other stressful stimuli like H2O2 [43] is well-documented [44]. However, there are conflicting reports on the potential effects of this cytokine in stroke. Some studies have found that the external administration of IL-6 in ischemic animal models leads

• br Materials and methods br

  2021-09-24

  

  Materials and methods Results Discussion Here, we investigated the inhibitory effects and associated mechanisms of phloroglucinol on α-glucosidase. Our results showed that phloroglucinol reversibly inhibited α-glucosidase in a dose-dependent manner (Fig. 1), with the double-reciprocal plot

• To evaluate SLC A abundance after

  2021-09-24

  

  To evaluate SLC45A1 abundance after transfection, we performed western blots. Transfected COS-7 NCT-502 were lysed and separated for membrane fraction. Equal amounts of proteins from membrane fractions were resolved by SDS-PAGE, transferred to a nitrocellulose filter, and immunoblotted with an anti

• br Materials and methods br

  2021-09-24

  

  Materials and methods Results Discussion In this study, we discover that Sufu stabilizes Gli1 protein levels by antagonizing Numb/Itch-mediated protein degradation. Together with previous work that demonstrates control of Gli2/3 protein levels by Sufu (Chen et al., 2009, Jia et al., 2009, W

• Protease Inhibitor Cocktail (100X in DMSO, EDTA plus) Abilit

  2021-09-24

  

  Ability of D-Ala2GIP to attenuate the neurobehavioral sequelae in QA-induced Huntington's disease model by reduction in lipid peroxidation, restoration of endogenous antioxidants and decreased striatal monoamine levels is of potential interest. Considerable preclinical evidence now exists of the pot

• br Introduction Calorie restriction CR

  2021-09-24

  

  Introduction Calorie restriction (CR), in the absence of malnutrition, has beneficial effects on aspirin solubility function, including reducing the incidence of age-related neurodegenerative disease (Gräff et al., 2013), eliciting anti-depressant behavior (Lutter et al., 2008) and improving mem

• This study introduces a mouse model carrying the point mutat

  2021-09-24

  

  This study introduces a mouse model carrying the point mutation R258W in Ffar1, which abolishes the stimulation of insulin secretion in response to long chain fatty acids. The minimal genetic alteration mirrors the human situation and has the advantage over conventional knockout/congenic mouse model

• br Introduction The term autophagy

  2021-09-24

  

  Introduction The term “autophagy” was coined by Christian de Duve in 1963 to describe the process of removing and degrading intracellular components such as unused proteins and damaged organelles through lysosomes [1,2]. Autophagy has been divided into three main types, namely, macroautophagy, mi

• br Site of expression FASTK is

  2021-09-24

  

  Site of expression FASTK is expressed in various parts of human body including heart, skeletal muscle, brain, placenta, lung, liver, kidney pancreas (Ota et al., 2004) and many other organs (Fig. 1). It has been reported that FASTK is highly expressed in pancreatic tumors, where it is involved in

• Limited efforts were made to exploit the naturally

  2021-09-23

  

  Limited efforts were made to exploit the naturally-occurring antigen-specific Treg for ex vivo expansion. This study sets up a reproducible protocol for the expansion of insulin-specific Treg isolated from NOD mice. These formyl peptide receptors exhibited higher suppressive capacity compared to th

• Sepsis was defined as a systemic

  2021-09-23

  

  Sepsis was defined as a systemic inflammatory response syndrome (SIRS) associated with severe infection in 1992 [9]. However, in the Third International Consensus Definitions for Sepsis and Septic Shock [10], it was redefined as life-threatening organ dysfunction provoked by a dysregulated host resp

• br Results and discussion A diverse set of compounds were

  2021-09-23

  

  Results and discussion A diverse set of compounds were synthesized to improve the PK and physicochemical properties of 2. Compounds' agonist effects on hGPR40 were assessed by calcium mobilization assay using hGPR40-HEK293 cell line which stably expressed human GPR40. Preliminary explorations fo

• The regulation of the stem cell compartment in CML

  2021-09-23

  

  The regulation of the stem cell compartment in CML is dynamic, in particular, during disease progression to a blast crisis and might involve a complex cross-regulation of Hh, Wnt, Notch, and hox signaling pathways (). Significant upregulation of Ptch1 and cyclin D1, upon other proteins, marks the bl

• Immunohistochemistry analysis shown ghrelin and GHSR a immun

  2021-09-23

  

  Immunohistochemistry analysis shown ghrelin and GHSR-1a immunostaining was located in the epithelial cells of Ion Channel Compound Library and ducts throughout the lactation, strong immunoreactive cells were detected in L30, L60 and L120 stage. The distribution of ghrelin has been shown in many tis

16396 records 604/1094 page Previous Next First page 上5页 601602603604605 下5页 Last page