• Graphic b shows that this paper was not cited

  2018-10-30

  

  Graphic 2b shows that this paper was not cited frequently during its first twenty years; however, from 1998 on, the citation line changes dramatically its inclination. II – Lucas\'s influences One of the functions of a relevant study in the History of Ideas is to provide to the public a better c

• Most detection methods analyzing DNA methylation

  2018-10-30

  

  Most detection methods analyzing DNA methylation rely on bisulfite conversion of DNA allowing for the detection of single CpGs while at the same time impeding further PCR amplification and thus, analysis of additional regions of interest. This limits detection of methyl-specific priming (MSP) to 10

• To confirm the presence of gyrA or gyrA

  2018-10-30

  

  To confirm the presence of gyrA83 or gyrA87 mutations in qPCRgyrALp-positive samples, we tried to PCR-amplify and sequence a 383-bp fragment of the L. pneumophila gyrA QRDR directly from eight respiratory samples of patients #1 to #4 (Table 1). Using next-generation deep sequencing (NGS) technology,

• Our second objective was to

  2018-10-30

  

  Our second objective was to analyze whether certain physician characteristics may play a role in these diagnostic and therapeutic decisions. In contrast to what might have been expected, younger cardiologists were not more aggressive than older ones. In fact, if anything, the reverse trend was obser

• Many clinical trials have suggested SC

  2018-10-30

  

  Many clinical trials have suggested SC efficacy. While early trials have focused on attempting to show improvements in morphologic measures such as left ventricular ejection fraction (LVEF), end diastolic volume (LVEDV), end systolic volume (LVESV), ventricular mass and scar size, others have attemp

• Finally we searched the Allele Frequencies in Worldwide

  2018-10-30

  

  Finally, we searched the “Allele*Frequencies in Worldwide Populations” (http://www.allelefrequencies.net/) website for known haplotypes related to the 6 discriminating alleles, within the 3 databases that we used. Haplotype information was available only for the SF database, as shown in Table 5. It

• We explored temporal patterns of the temperature

  2018-10-30

  

  We explored temporal patterns of the temperature-outcome relationship (lags) for all diseases (Supplementary File 7). We pooled heat effects as a) lag 0, 1 and 0–1, and b) above lag 2, and cold effects as a) lag 15. The risk for heat-related CVD mortality was greatest for lag 0–1; 4.15% (3.7–4.59) r

• br Funding Sources This project was supported by

  2018-10-30

  

  Funding Sources This project was supported by NIH grants AI081545 (NL) and AI122209 (MS) and BU Pilot Grant (MS). No author received compensation from a pharmaceutical company or other agency for completion of this manuscript. Conflict of Interest Statement Author Contributions Acknowle

• In addition to the cyclic guanosine

  2018-10-30

  

  In addition to the cyclic guanosine monophosphate-dependent protein kinase pathway, NO is known to regulate the function of target proteins through S-nitrosylation of cysteine residues (Hess et al., 2005; Jaffrey et al., 2001). One such target is the type 1 ryanodine receptor (RyR1), which is the Ca

• Cofilin partners with the Arp and WAVE complex to

  2018-10-29

  

  Cofilin 1 partners with the Arp2/3 and WAVE complex to stimulate the formation of dendritic actin, which is an essential step for cell protrusion and invasion (Ichetovkin et al., 2002; Desmarais et al., 2005; Beaty and Condeelis, 2014; Bravo-Cordero et al., 2013). Both pathways are activated by the

• For the calculation of the

  2018-10-29

  

  For the calculation of the bulk value of the Young׳s modulus the simplest choice is a 2-atom tetragonal unit cell with cell vectors along [], [110], and [001]:This cell, however, does not allow to introduce twin boundaries. Therefore, the calculation of was repeated for a second, 6-atom orthorhombic

• nonreceptor tyrosine kinase br Materials and methods br Ackn

  2018-10-29

  

  Materials and methods Acknowledgments We would like to thank all members of the Imhof and Heun group for critical discussions and feedback and the anonymous reviewer for valuable comments and suggestions to improve the manuscript. Work in the lab of A.I. was supported by grants from the German

• Figs and compares the different dynamic

  2018-10-29

  

  Figs. 1 and 2 compares the different dynamic of substrate and product as revealed by their distance profiles with the catalytic Ser221 (see Fig. 1) and the r.m.s.d. values as computed considering the ligand atoms only. Fig. 3 compares the pull force profiles along the x axis of the undocking process

• br Acknowledgments This work was financially supported

  2018-10-29

  

  Acknowledgments This work was financially supported by Simon Fraser University, Stem Cell Network of Canada, Compute Canada, and Westgrid. Y. Z. was supported in part by NNSFC (National Natural Science Foundation of China), Grant no. 21336009. Data The desmosomal cadherin, Desmoglein 3 (Dsg3)

• br Experimental design materials and methods br Funding

  2018-10-29

  

  Experimental design, materials and methods Funding sources This research was supported by 2014 Research Grant from Kangwon National University (No. 120141458) and Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2016R1A

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