• In silico docking analysis performed in the

  2024-05-21

  

  In silico docking analysis performed in the current study indicated that TCDD strongly binds to AhR-LBD. Moreover, the formation of the TCDD/AhR-LBD complex was confirmed experimentally with the use of EMSA. We found that 10nM TCDD after 2 hours of incubation not only bound to the AhR in the porcine

• br Expression of ADK in the normal brain In adult

  2024-05-20

  

  Expression of ADK in the normal brain In adult brain, ADK is primarily expressed in astrocytes. Immunocytochemical analysis of adult rat and mouse pgp inhibitors revealed predominant astrocytic expression throughout the hippocampus and cortex. Two isoforms of ADK have been identified in mammals,

• br AMPK structure and mechanism of action AMPK is

  2024-05-20

  

  AMPK: structure and mechanism of action AMPK is a metabolic master switch that regulates downstream signals based on shifts in the surrounding energy reservoir [6]. It is expressed in a number of tissues, including the kidney, the liver, the skeletal muscle, the adipose tissue, and the hypothalam

• There is also a literature on the impact of commodity

  2024-05-20

  

  There is also a literature on the impact of commodity (consumption) taxation under imperfect competition. Besley (1989) applies a Cournot model, in which production takes place under IRS and in which free entry leads to an excessive number of firms in the market. Introducing a distortive specific co

• AXL is a member of the TAM Tyro Axl

  2024-05-20

  

  AXL is a member of the TAM (Tyro3, Axl, Mer) family of receptor tyrosine kinases (RTKs) [4]. Elevated AXL expression could promote oncogenic processes such as cell growth, migration, invasion, and epithelial-to-mesenchymal transition (EMT), which substantially contribute to tumor progression and poo

• neuroscience peptides Phospholipases cleave membrane phospho

  2024-05-20

  

  Phospholipases cleave membrane phospholipids from inflammatory cells, activated platelets, erythrocytes, adipocytes and cancer neuroscience peptides (Aoki et al., 2008, Neidlinger et al., 2006). Several reports have analysed the role of LPA and its receptors in the pathogenesis of RA. Zhao et al. r

• The earliest appearance of tumors occurred at months and

  2024-05-20

  

  The earliest appearance of tumors occurred at 12 months and the latest at 24 months, with an average onset at 18 months (Fig. 1B). This would be roughly equivalent to cancer presenting in a patient between 60 and 70 years of age. In transgenic animals, autotaxin 76 2 mg was relatively increased in

• Beside estrogen several classes of compounds have shown sign

  2024-05-20

  

  Beside estrogen, several Cy5 amine (non-sulfonated) of compounds have shown significant neuroprotective efficacy when administered shortly after the induction of animal models of stroke, including glutamate (NMDA) receptor antagonists and zinc chelators [25], [26], [27]. Effects of these or other n

• We demonstrated clearly that the

  2024-05-20

  

  We demonstrated clearly that the overexpression of sFlt-1 significantly increased arginase SU6656 and enhanced arginase activity in HUVECs (Fig. 3). NO formation is related inversely to serum levels of sFlt-1 in preeclampsia [11]. The disorder of NO formation, which was involved in hypertension and

• br Apelin The APJ receptor ligand apelin

  2024-05-20

  

  Apelin The APJ receptor ligand apelin firstly in 1998 was segregated from bovine stomach tissue. Human preproapelin gene located on chromosome Xq25–26.1. The apelin preproproteins consist of 77 amino MHY1485 residues that are cleaved into biologically active C-terminal fragments of various sizes

• That increased longevity was not the exclusive result of blo

  2024-05-20

  

  That increased longevity was not the exclusive result of blood pressure reduction. This was demonstrated by analysis of life-long, whole body deletion of AT1A receptors in normotensive mice. These animals exhibited a very significant increase in lifespan when compared to wild- type mice [159], [160]

• Another class of AMPK regulator is peptidyl prolyl

  2024-05-20

  

  Another class of AMPK regulator is peptidyl-prolyl cis/trans isomerase (PPIase) NIMA-interacting 1 (Pin1), which binds to a number of proteins and regulates oncogenesis and metabolic diseases (Khanal et al., 2013; Zhou and Lu, 2016). Pin1 has been shown to bind to and inhibit AMPK; therefore, at lea

• There are several strengths and weaknesses

  2024-05-18

  

  There are several strengths and weaknesses of the current investigation which merit consideration. Obviously, the current findings are important and less prone to bias than findings from traditional observational epidemiological studies, because causal investigations with the use of genetic variants

• br Downstream signalling of AKT A consensus phosphorylation

  2024-05-18

  

  Downstream signalling of AKT A consensus phosphorylation motif has been described for AKT substrates: R-X-R-X-X-S/T-B where X represents any amino PFI 3 and B represents bulky hydrophobic residues (Alessi, Caudwell, Andjelkovic, Hemmings, & Cohen, 1996). Numerous AKT substrates have been publis

• Aberrant or a sustained activation of

  2024-05-18

  

  Aberrant or a sustained activation of AhR signaling pathway, triggered by exogenous toxic ligands such as dioxins, PAHs or polychlorinated biphenyls (PCBs), is a well-described biological process engaged during tumor initiation and/or promotion in various tissues (e.g. liver, lung, skin)(reviewed in

15723 records 101/1049 page Previous Next First page 上5页 101102103104105 下5页 Last page