• br Patients and methods br Discussion In this secondary endp

  2019-06-05

  

  Patients and methods Discussion In this ubiquitin activating enzyme secondary endpoint analysis of the OPTION trial, we have shown that the addition of goserelin to neo(adjuvant) chemotherapy temporarily increased bone turnover during treatment and that this reverses over the next 6–12 months

• br Homing of DTCs to the HSC

  2019-06-05

  

  Homing of DTCs to the HSC niche The HSC niche is a complex microenvironment comprised of many cell types, including endothelial cells, adipocytes, osteoclasts, osteomacs, and cmv virus of osteoblastic lineage [5]. A healthy HSC niche provides homing signals to healthy HSCs in order to promote th

• LQTS is classified into subtypes LQT to LQT based

  2019-06-05

  

  LQTS is classified into subtypes LQT1 to LQT13 based on the site of genetic mutation. Each type possesses distinct clinical characteristics and a different prognosis. Treatment choice depends partly on individual phenotype and partly on genotype. Among Asian countries, several reports have been publ

• Fischer and colleagues also raise

  2019-06-01

  

  Fischer and colleagues also raise concerns about the fact that MHSP “only offers testing to men”. As previously stated, MHSP is a public health programme based on the principles outlined in WHO\'s interim guidelines. The focus of that guidance is preventing sexual transmission of Ebola virus by men

• After overdrive pacing excitation that is one lap behind the

  2019-06-01

  

  After overdrive pacing, excitation that is one lap behind (the second beat after the stimulus) is caused by several mechanisms. One is the prolonged conduction time that is longer than the TCL due to a long conduction pathway and/or slow conduction. The other is the dual-loop reentry [12]. The excit

• Los muy adeptos Fouchet y Joffroy

  2019-06-01

  

  Los muy adeptos Fouchet y Joffroy publican sus artículos al calor de la impactante edición francesa de Gallimard, segunda en aparecer (Aub, 1961). Que Aub lograse colocar su obra en el catálogo del sello más importante de Francia se debe, más que al regular contacto con su lugar de nacimiento, mtor

• In Tara Mangal and colleagues report

  2019-06-01

  

  In , Tara Mangal and colleagues report the results of their case-control study into the persistence of poliomyelitis in Nigeria, which identified low vaccine efficacy, poor vaccine coverage, suboptimum buy adenosine triphosphate immunity, rejection and refusal of vaccine, and lack of awareness as i

• Fourth the enormous investment in

  2019-06-01

  

  Fourth, the enormous investment in accessible medicines and medical products without investment in checking their quality is profoundly illogical. WHO estimates that only 7% of sub-Saharan countries had a “moderately functioning MRA”. We cannot expect the world\'s medicine supply to improve without

• When the analysis was matching with propensity

  2019-06-01

  

  When the analysis was matching with propensity score, OS was still significantly longer in JAK2+ patients (median not reached versus 73 months, p=.031) whereas JAK2 status had no significant prognostic value for OS in IPSS intermediate-2 and high patients (p=.18). Discussion In this series, whic

• br Discovery of S PR as a CBA

  2019-06-01

  

  Discovery of S1PR2 as a CBA sensor in the liver Early studies reported that activation of the ERK1/2 and AKT signaling pathways by CBAs was PTX-sensitive, suggesting a role for a Gαi-linked GPCR. To identify which GPCR activates the ERK1/2 and AKT signaling pathways, the cDNAs encoding more than

• Bone marrow resident Macs Osteomacs

  2019-05-31

  

  Bone marrow resident Macs (Osteomacs) are located in canopy-like structures in endosteal and periosteal surfaces, above osteoblasts [6]; osteoclasts result from the fusion of several myeloid osteoclast precursors [7]. Osteomacs constitute approximately 17% of the bone marrow ap5 and they differ fro

• br Material and methods br Results br Discussion Previously

  2019-05-31

  

  Material and methods Results Discussion Previously, various small studies reported that CRT is an effective therapy in patients with NAHF [7,10–15]. These studies demonstrated favorable outcomes in patients treated with CRT, including the ability to wean patients from intravenous inotropes

• br The introduction of direct acting

  2019-05-31

  

  The introduction of direct-acting antiviral drugs (DAAs) is changing the treatment options for hepatitis C facial expression (HCV). These new medicines were initially marketed at a very high price, but several countries have negotiated favourable price reductions, and, in view of the low cost of

• br Results br Discussion The results of this

  2019-05-31

  

  Results Discussion The results of this retrospective study demonstrate the feasibility and safety of combined left atrial catheter ablation and Watchman® implant procedures with satisfactory LAA occlusion maintained at follow-up. The rates of successful device implantation and complete LAA occ

• br Ocular surface squamous neoplasia OSSN

  2019-05-30

  

  Ocular surface squamous neoplasia (OSSN) has emerged as an important manifestation of the HIV epidemic, especially in sub-Saharan Africa. This region has not only gained the unenviable position of having the highest prevalence of OSSN, but patients with HIV tend to present with larger tumours and

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